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Thanos is a Titan, which makes him bigger and stronger than the other beings in the universe, before he could lay his hands on all the infinity stones and their power.
Steve Rogers became Captain America when he was given the Super-Soldier Formula and Vita Rays to give him superhuman strength, agility, stamina, and more.
Yet another Asgardian, Hela is one of the most powerful villains in the Marvel universe. He helped his father Odin with Mjolnir conquer the nine.